Former Pfizer researchers work together to fight diarrhea in developing nations

Diarrhea kills nearly two million children under the age of five each year.  It is the world’s second leading cause of death in this age group.  Most of the affected children live in developing countries, and have limited access to clean water and modern medical facilities.

Peter Ruminski, executive director of Saint Louis University Center for World Health and Medicine
Peter Ruminski, executive director of Saint Louis University Center for World Health and Medicine.
Photo courtesy of Saint Louis University

“When children in this country develop severe diarrhea and become lethargic, their parents can take them to the emergency room for IV fluids,” explains Pete Ruminski, executive director of Saint Louis University’s Center for World Health and Medicine.  “Even if the diarrhea isn’t severe enough for hospitalization, pediatricians routinely replenish fluid and electrolytes with Gatorade or its equivalent dissolved in clean water.”

Diarrhea can have many causes.  Cholera often accompanies major disasters.  Infection by amoeba, viruses such as rotavirus, and parasites like giardia all result in the cramping and loss of water and electrolytes in this potentially lethal syndrome.  The bacterial E. coli epidemic that has recently sickened thousands of Europeans has diarrhea as one of its manifestations.

Except for opiates, the main drug available to treat the symptoms of diarrhea is Immodium.  Immodium keeps the large intestine from contracting, but is not recommended for use in young children.

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Scientist thrives on challenge and change

Phil Needleman relishes his new role as Interim President and CBO of the Saint Louis Science Center.

“What’s good about an interim president is that it means change,” he exults.  “It is the death of ‘the way we’ve always done it.'”

Having just finished another stint as interim head of an institution—nearly two years at the Donald Danforth Plant Science Center– he knows whereof he speaks.

According to Sam Fiorello, COO of the Danforth Center, he left that research institute in better shape than when he came.

Philip Needleman, Ph.D.
Philip Needleman, Ph.D.
Photo courtesy of Saint Louis Science Center

Needleman has lost none of his gusto for anything to do with science since he first came to St. Louis in 1964 as a postdoctoral fellow in the Department of Pharmacology at Washington University Medical School.  His enthusiasm—always conveyed with a wide smile and his St. Louis-tempered Brooklyn accent—has shaped the environment of in all of his workplaces.

He spent 25 years at Washington U, leaving his position as Professor and Head of the Department of Pharmacology to become Chief Scientist at Monsanto.  The move to industry was prompted by what he felt was a unique opportunity to follow his research all the way from basic science through development and eventual marketing of a drug.

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